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KMID : 0363320080290041100
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 4 p.1100 ~ p.1114
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The Effects of Rehmannia on Nephrectomy-induced Chronic Renal Failure Rats
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Choe Jong-Bae
Kim Yong-Sung
Han Yang-Hee
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Abstract
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The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine. total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehrnannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 (AT₁) receptor) of the Rehmanala-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.
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KEYWORD
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Rehmannia, Nephrectomy, Chronic renal failure
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